Inhibition of zebrafish epidermal growth factor receptor activity ...
2003年7月1日 · We isolated a zebrafish homologue of EGFR (egfr) that shows a 63% amino acid overall identity to human EGFR but with 90% amino acid identity in the kinase domain. Whole …
Disruption of Epidermal Growth Factor Receptor but Not EGF …
2022年1月17日 · In this study, we created zebrafish mutants for Egf ( egf -/- ) and Egfr ( egfra -/- and egfrb -/- ) by CRISPR/Cas9 technique. Surprisingly, these mutants all survived well with …
Developmental defects in zebrafish for classification of EGF …
2014年1月15日 · Here we used the zebrafish to define several developmental defects caused by impairment of Egf signaling, a major pathway of interest in tumor biology. We inactivated Egf …
Disruption of Epidermal Growth Factor Receptor but Not EGF …
2022年1月16日 · Using CRISPR/Cas9-mediated gene knockout approach, we investigated the functional importance of Egf/egf and Egfr (egfra and egfrb) in the zebrafish with particular …
EGFR-dependent endocytosis of Wnt9a and Fzd9b promotes β
2024年4月16日 · Wnt9a signals through Fzd9b, the co-receptor LRP5 or LRP6 (LRP5/6), and the epidermal growth factor receptor (EGFR) to promote early proliferation of zebrafish and human …
Epidermal growth factor receptor promotes high-fructose …
2023年4月16日 · Our results demonstrated that EGFR was activated in hepatocytes from high fructose (HF)-induced NAFLD zebrafish and interfered with Mfn1 polymerization, leading to …
Cloning of Epidermal Growth Factor (EGF) and EGF Receptor from …
2004年9月1日 · In the present study, we cloned full-length cDNAs for epidermal growth factor (EGF), EGF receptor (EGFR), and three truncated forms of EGFR (EGFR15, 12, and 8) from …
Attenuating the Epidermal Growth Factor Receptor-Extracellular …
In the zebrafish liver injury model, both hepatocytes and biliary epithelial cells contributed to LPCs. EGFR inhibition promoted the differentiation of LPCs regardless of their origin. Notably, …
Evolutionarily conserved regulation of sleep by epidermal growth …
Using the zebrafish, a diurnal vertebrate, to investigate the genetic regulation of sleep, we found that epidermal growth factor receptor (EGFR) signaling is necessary and sufficient for normal …
Inhibition of zebrafish epidermal growth factor receptor activity ...
We isolated a zebrafish homologue of EGFR (egfr) that shows a 63% amino acid overall identity to human EGFR but with 90% amino acid identity in the kinase domain. Whole mount in situ …
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