Heparin in inflammation: potential therapeutic applications beyond ...
In this chapter we have described anti-inflammatory functions of heparin distinct from its traditional anticoagulant activity. We have presented in vivo data showing heparin's beneficial effects in various preclinical models of inflammatory disease as …
The anti-inflammatory effects of heparin and related compounds
2020年8月7日 · This review presents some of the evidence from clinical and animal studies supporting an anti-inflammatory role for heparin and heparin-related derivatives. Potential mechanisms by which heparin can exert its anti-inflammatory effects are discussed.
Heparin’s anti-inflammatory effects require glucosamine 6-O …
Here we show that the potent anti-inflammatory property of heparin results primarily from blockade of P-selectin and L-selectin. Unfractionated heparin and chemically modified analogs were tested as inhibitors of selectin binding to immobilized sialyl Lewis X and of cell adhesion to immobilized selectins or thrombin-activated endothelial cells.
The anti-inflammatory effects of heparin and related compounds
2008年1月1日 · The potential of heparin as an anti-inflammatory drug is supported by several modestly sized clinical trials in various models of inflammatory disease. Heparin and related compounds have been shown to benefit patients with bronchial asthma, ulcerative colitis and …
More than an anticoagulant: Do heparins have direct anti-inflammatory …
2017年2月28日 · The heparins, well-known for their anticoagulant properties, may also have anti-inflammatory effects that could contribute to their effectiveness in the treatment of venous thromboembolism and other vascular diseases. This review focuses on the inflammatory pathophysiology that underlies the develop …
Heparin in Inflammation: Potential Therapeutic Applications …
1999年1月1日 · Heparin and related molecules have been shown to provide benefit in various preclinical models of inflammatory disease including asthma, emphysema, adult respiratory distress syndrome (ARDS), DTH, experimental autoimmune encephalomyelitis (EAE), ischemiaz–reperfusion injury, and circulatory shock and related disorders.
Molecular Mechanism of the Anti-Inflammatory Action of Heparin
Our investigations reveal another facet of heparin: a potent anti-inflammatory agent due to its ability to engage with two of the key cytokines in the development of the cytokine storm, IFNγ and IL-6, thus downregulating their biological activity.
The Preventive and Therapeutic Effects of Acute and Severe Inflammatory …
2024年8月28日 · In this paper, the main findings regarding the molecular mechanisms associated with the beneficial effects of heparin, including inhibiting HMGB-1-driven inflammation reactions, histone-induced toxicity, thrombo-inflammatory response control and the new emerging mechanisms are concluded.
The dual face of heparin in severe infection - American Society …
2014年2月13日 · The article of Wildhagen et al describes a novel and interesting immune-modulating mechanism of heparin. 1 Heparin has a strong affinity for extracellular histones that result from cellular destruction during severe inflammation and that are robustly associated with endothelial dysfunction, organ failure, and death during sepsis 5 (see figure).
Heparin, Low Molecular Weight Heparin, and Non-Anticoagulant …
2023年4月13日 · Heparin has multiple anti-inflammatory, mucoactive, and anti-microbial pharmacological properties (Figure 2) with the potential to limit multiple aspects of the inflammatory response, including endothelial adhesion, migration and activation of leukocytes, and neutralisation of released tissue-damaging mediators (reviewed in [4]).