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2024年12月12日 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware ...
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eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science.
Three-dimensional single-cell transcriptome imaging of thick …
2024年12月27日 · By integrating multiplexed error-robust fluorescence in situ hybridization (MERFISH), deep learning, optical sectioning, and protocol optimization, thick-tissue 3D MERFISH allows volumetric single-cell transcriptome imaging of thick-tissue samples, broadening the scope of applications of spatial genomics.
Impairment of lipid homeostasis causes lysosomal accumulation of ...
2024年12月23日 · Protein aggregation is a hallmark of aging and age-related pathologies, including multiple neurodegenerative diseases and amyloidoses that affect individual or multiple organs (Chiti and Dobson, 2017; Eisenberg and Jucker, 2012).Dozens of proteins that are normally soluble may form aggregates that are traditionally associated with specific diseases – e.g. tau tangles and amyloid plaques with ...
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eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd ...
Hematopoiesis: Counting blood precursors - eLife
2024年7月17日 · Experiments with the Confetti reporter system in mice revealed that hundreds of HSPCs in the embryo contribute to hematopoiesis in adults, and that expansion of these precursors is limited in the fetal liver (Ganuza et al., 2017; Ganuza et al., 2022).However, the previous mathematical model used to quantify the number of precursors was only tested for cell counts between 50 and 2,500 cells ...
Luminal epithelial cells integrate variable responses to aging into ...
2024年11月15日 · One of the main risk factors for breast cancers is aging. But how exactly aging contributes to breast cancer is not fully understood. The mammary gland is the part of the breast that can produce milk, and is composed of two major cell types: luminal epithelial cells and myoepithelial cells. Most age-related breast cancers are thought to originate from luminal epithelial cells, but some age ...
Science Forum: Antibody characterization is critical to enhance
2024年8月14日 · Antibodies are critical reagents used in a variety of assays and protocols in biomedical and clinical research. The ability to detect, quantify, enrich, localize, and/or perturb the function of a target protein – even when present in a complex protein mixture, such as a cell lysate or tissue slice, or even in an intact organism – is key to many biomedical research studies.
Evaluating the transcriptional regulators of arterial gene …
6 天之前 · Mutations in Sonic Hedgehog (SHH) signaling pathway genes, for example, Suppressor of Fused (SUFU), drive granule neuron precursors (GNP) to form medulloblastomas (MB SHH).However, how different molecular lesions in the Shh pathway drive transformation is frequently unclear, and SUFU mutations in the cerebellum seem distinct. In this study, we show that fibroblast growth factor 5 (FGF5 ...
Neuronal Development: Rethinking sensorimotor circuits | eLife
2024年11月13日 · For decades, scientists have theorised that motor neurons have an essential role during the development of sensorimotor circuits that involves specifying the fate of the projection neurons (Glover, 2000; Glover, 2003).This ‘retrograde specification model’ was in part inspired by the observation that extraocular motor neurons establish connections with muscle cells before projection neurons ...