The role of human mast cells in allergy and asthma - PMC
Mast cells contribute to asthma symptoms by triggering bronchoconstriction and altering the permeability of the bronchial barrier. They also recruit other immune cells and promote their …
The role of the mast cell in the pathophysiology of asthma
There is compelling evidence that human mast cells contribute to the pathophysiology of asthma. Mast cells, but not T cells or eosinophils, localize within the bronchial smooth muscle bundles …
Human Lung Mast Cells: Therapeutic Implications in Asthma
Mast cells are strategically located in different compartments of the lung in asthmatic patients. These cells are widely recognized as central effectors and immunomodulators in different …
The role of the mast cell in the pathophysiology of asthma
2006年6月1日 · There is compelling evidence that human mast cells contribute to the pathophysiology of asthma. Mast cells, but not T cells or eosinophils, localize within the …
Mast Cells and Their Progenitors in Allergic Asthma
Mast cells are key players in the asthmatic response through secretion of a multitude of mediators with pro-inflammatory and airway-constrictive effects. Well-known mast cell mediators, such as …
Mast cells in asthma: Here I am, stuck in the middle with you
Mast cells play an important role in allergic lung inflammation in asthma, contributing to both the early-phase reaction as well as the late-phase reactions of asthma through the release of …
Mast Cells and Their Progenitors in Allergic Asthma - PubMed
2019年5月29日 · In allergic asthma, mast cells become activated mainly via IgE-mediated crosslinking of the high affinity receptor for IgE (FcεRI) with allergens. However, mast cells can …
The role of human mast cells in allergy and asthma - PubMed
FcεRI-activated mast cells are known to release histamine and proteases that contribute to asthma symptoms. They release a variety of cytokines and lipid mediators that contribute to …
IgE and mast cells in allergic disease | Nature Medicine
2012年5月4日 · In this review, we discuss findings supporting the conclusion that IgE and mast cells can have both interdependent and independent roles in the complex immune responses …
Role of mast cells in allergic and non-allergic immune ... - Nature
Mast-cell mediators affect the mucosa, the blood vessels and sensory nerves at sites of allergy; mast-cell proteases and cytokines contribute to the initiation of a facultative late-phase...