Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient ...
In this review, we summarize diverse regulatory mechanisms of SLC7A11 in cancer, discuss ferroptosis-dependent and -independent functions of SLC7A11 in promoting tumor …
SLC7A11 expression level dictates differential responses to …
2023年6月21日 · Recent studies have established ferroptosis as a key tumor-suppression mechanism and have shown that SLC7A11 overexpression in cancer cells promotes tumor …
METTL3 inhibition promotes radiosensitivity in hepatocellular …
2025年1月11日 · We proceeded to investigate whether SLC7A11 was involved in the METTL3-mediated ferroptosis regulation, by introducing SLC7A11 into METTL3 knockdown HepG2 or …
The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11
2019年4月15日 · In this study, we utilized biochemial purification to identify the ubiquitin hydrolase OTUB1 as a key factor in modulating SLC7A11 stability. OTUB1 directly interacted with and …
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, …
In this review, we summarize diverse regulatory mechanisms of SLC7A11 in cancer, discuss ferroptosis-dependent and -independent functions of SLC7A11 in promoting tumor …
The roles of ferroptosis regulatory gene SLC7A11 in renal cell ...
We comprehensively probed into the roles of Solute carrier family 7 member 11 (SLC7A11), a ferroptosis regulatory gene in prognosis, immune microenvironment, biological metabolism, …
SLC7A11 as a Gateway of Metabolic Perturbation and Ferroptosis …
2022年11月9日 · SLC7A11 is a critical gateway for redox homeostasis by maintaining the cellular levels of GSH that counter cellular oxidative stress and suppress ferroptosis. SLC7A11 is …
Ferroptosis as a p53-mediated activity during tumour suppression
2015年3月18日 · Here we show that p53 inhibits cystine uptake and sensitizes cells to ferroptosis, a non-apoptotic form of cell death, by repressing expression of SLC7A11, a key component of …
N6-methyladenosine RNA modification regulates the transcription …
2025年1月13日 · METTL3 triggered ferroptosis via suppressing SLC7A11 transcription. A The volcano plot showed the mutated genes between WT and METTL3 KD cells. B The overlap …
N6-methyladenosine RNA modification regulates the transcription …
2025年1月13日 · In vivo and clinical data supported the positive roles of the METTL3/SLC7A11 axis in tumor growth and progression. Conclusions: METTL3 regulated the transcription of …
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