动力蛋白轴丝重链 12（DNAH12）基因 | MCE - MCE-生物活性 ...
预计将启用多种功能，包括 ATP 绑定活动；动力蛋白中间链结合活性；和动力蛋白轻链中间链结合活性。 预计参与基于微管的运动。 预测位于纤毛中；细胞质；和微管。 预计是动力蛋白复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月] Predicted to enable several functions, including ATP binding activity; dynein intermediate chain binding activity; and dynein LIGHT intermediate chain binding activity. Predicted to be involved in microtubule-based movement.
Macrophage colony-stimulating factor induces the proliferation …
2009年6月7日 · Here we show DAP12 deficiency impaired the M-CSF-induced proliferation and survival of macrophages in vitro. DAP12-deficient mice had fewer microglia in defined central nervous system areas, and...
DNAH12 Gene - GeneCards | DYH12 Protein | DYH12 Antibody
2024年12月24日 · DNAH12 (Dynein Axonemal Heavy Chain 12) is a Protein Coding gene. Diseases associated with DNAH12 include Sulfonamide Allergy and Ciliary Dyskinesia, Primary, 3 . Gene Ontology (GO) annotations related to this gene include ATP hydrolysis activity and microtubule motor activity .
Deficiency in a special dynein DNAH12 causes male infertility by ...
2024年8月27日 · Through comprehensive genetic analyses involving whole-exome sequencing and subsequent Sanger sequencing on infertile patients and fertile controls from six distinct families, we unveiled six biallelic mutations in DNAH12 that co-segregate recessively with male infertility in the studied families.
DNAH12 protein expression summary - The Human Protein Atlas
RNA specificity category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.
Somatic mutation of DNAH genes implicated higher chemotherapy response ...
2019年4月3日 · In this study, we analyzed the genomic database to evaluate the mutation status of DNAH genes in gastric adenocarcinoma and further identified the significance of mutant DNAH genes as effective molecular biomarkers for predicting chemotherapy response in …
DNAH12 dynein axonemal heavy chain 12 [ (human)] - National …
2024年3月5日 · Predicted to enable several functions, including ATP binding activity; dynein intermediate chain binding activity; and dynein light intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to …
Q6ZR08 - UniProt
2009年4月14日 · Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring.
有动力蛋白轴丝重链基因家族变异的不育男性的有利生育结果-出生 …
2024年8月11日 · Collectively, our study indicated that biallelic variants of DNAH12 can induce male infertility in both human beings and mice. Notably, evidence from DNAH12 enhanced that ICSI was an optimal...
SingleMarker - Cell Taxonomy - CNCB-NGDC
The relevant cell types for DNAH12 are ranked by evaluation of supported literature, expression enrichment and conservation. This panel shows the cell types of the cell marker in various tissues.