Autoantibodies in SLE: Specificities, Isotypes and Receptors
Systemic Lupus Erythematosus (SLE) is characterized by a wide spectrum of auto-antibodies which recognize several cellular components. The production of these self-reactive antibodies fluctuates during the course of the disease and the involvement ...
Systemic Lupus Erythematosus - StatPearls - NCBI Bookshelf
2023年8月4日 · Several pathogenic autoantibodies have since been identified. Despite recent advances in technology and understanding of the pathological basis and risk factors for SLE, the exact pathogenesis is still not well known.
Lupus Blood Tests - Johns Hopkins Lupus Center
The anti-Sm antibody is usually measured by one of four methods: ELISA, counterimmunoelectrophoreses (CIE), immunodiffusion, or hemagglutination. Anti-U1RNP Antibody. Anti-U1RNP antibodies are commonly found along with …
Antibody Testing for Systemic Lupus Erythematosus - AAFP
2011年12月15日 · Antibody testing plays an important role when assessing patients, but should not be used alone to diagnose SLE. (Strength of Recommendation: C, based on expert opinion.) The antinuclear...
An update on autoantibodies in systemic lupus erythematosus
Autoantibodies are cornerstone biomarkers in systemic lupus erythematosus (SLE), an autoimmune disease characterized by autoantibody-mediated tissue damage. Autoantibodies can inform about disease susceptibility, clinical course, outcomes, and the etiology of SLE.
An Overview of Systemic Lupus Erythematosus (SLE) …
Antinuclear antibodies (ANA) are the telltale serological marker in more than 95% of SLE patients. The improved set of European Alliance of Associations for Rheumatology (EULAR) classification enabled accurate diagnosis of SLE. The treatment focuses on remission, preventing organ damage, and improving the overall quality of life.
Autoantibodies in systemic lupus erythematosus: From …
2022年10月1日 · Systemic lupus erythematosus (SLE) is a severe autoimmune disease characterized by autoantibodies accumulation, immune complex deposit, and inflammatory damage on various target organs as a result of failure of immune tolerance.
An update on autoantibodies in systemic lupus erythematosus
2023年3月1日 · Recent studies showed that levels of autoantibodies against dsDNA, C1q, chromatin, Sm and ribosomal P may serve as biomarkers of proliferative lupus nephritis, and identified novel autoantibodies to several unique species of …
Autoantibodies in SLE: Specificities, Isotypes and Receptors
2016年1月4日 · In this review, we describe the different auto-antibodies reported to be involved in SLE. How autoantibody isotypes and affinity-binding to their antigen might result in different pathogenic responses is also discussed. Keywords: Fc …
Autoantibodies in systemic lupus erythematosus: From …
2022年10月1日 · Autoantibodies of SLE is highly heterogenous. Identification of the pathogenic autoantibodies will improve the specificity of the treatment for SLE. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ inflammatory damage and wide spectrum of autoantibodies.