S100P is a ferroptosis suppressor to facilitate hepatocellular ...
2025年1月8日 · Here, our study confirms that S100 calcium binding protein P (S100P), which is significantly up-regulated in ferroptosis-resistant HCC cells, efficiently inhibits ferroptosis. …
LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty ...
2020年9月3日 · Upon induction of ferroptosis, AMPK is activated by upstream kinase LKB1, leading to the inhibition of cellular lipid synthesis by inhibitory phosphorylation of ACC1 and …
Ferroptosis: molecular mechanisms and health implications - Nature
2020年12月2日 · Acetyl-CoA carboxylase alpha (ACACA/ACC1), a central enzyme involved in fatty acid β-oxidation and fatty acid biosynthesis, plays a context-dependent...
The Role of AMP-activated Protein Kinase in Oxytosis/Ferroptosis ...
Recent Advances: Recently, several studies have identified a protective role for the AMP-activated protein kinase (AMPK)/acetyl CoA carboxylase 1 (ACC1) pathway in …
Unraveling ETC complex I function in ferroptosis reveals a …
Here, we reveal that pharmacological inhibition of the ETC complex I reduces ubiquinol levels while decreasing ATP levels and activating AMP-activated protein kinase (AMPK), the two …
Genome-wide synthetic lethal screen unveils novel CAIX-NFS1
2021年8月27日 · Inhibition of ACC1 decreased cell death of both erastin combinations in a dose-dependent manner, suggesting that the signal transmitted from AMPK to ACC1 is biologically …
Energy Stress Inhibits Ferroptotic Cell Death via AMPK Activation
2020年4月1日 · Mechanistically, additional experiments suggested this ferroptosis inhibition was dependent on phosphorylation of acetyl-CoA carboxylase 1 and 2 (ACC1/2) by AMPK, which …
GLUT1 exacerbates trophoblast ferroptosis by modulating …
2024年12月20日 · In this study, placentas from GDM patients with FGR showed signs of ferroptosis and upregulation of GLUT1. In cell models, high glucose conditions sensitized …
Energy stress inhibits ferroptosis via AMPK - Taylor & Francis …
2020年5月21日 · AMPK-mediated phosphorylation of acetyl-CoA carboxylase (ACC) on serine 79 (of ACC1) or serine 212 (of ACC2) inhibits fatty acid synthesis and promotes its oxidation.
Acetyl-CoA carboxylase 1 controls a lipid droplet ... - Science
2024年2月28日 · Bacci et al. report that acetyl-CoA-carboxylase-1 (ACC1) promotes lipid mobilization in estrogen-deprived breast cancer cells, leading to anti-estrogen therapy …