Researchers have discovered how a particular protein affects the growth and spread of colon cancer in humans. The study not ...

A research team revealed that insulin-like growth factor-binding protein 6 (IGFBP6) serves as a potential therapeutic target ...

mitogen activated protein kinase MAP kinase anti-inflammatory signal transduction Proper regulation ... evolutionarily conserved family of enzymes that form a highly integrated network required to ...

To further probe Mediator kinase function, we completed cytokine screens and metabolomics experiments. Cytokines are master regulators of inflammatory responses; by screening 105 different cytokine ...

The three-dimensional shape of a protein can be used to resolve deep, ancient evolutionary relationships in the tree of life, ...

For children with severe hypertrophic cardiomyopathy caused by gain-of-function RAS/mitogen-activated protein kinase ( ...

Researchers have innovatively merged protein structural data with genetic sequences to construct evolutionary trees, ...

G protein-coupled receptor kinase 2 (GRK2) is involved in heart failure (HF) progression and its upregulation contributes to adverse cardiac remodeling and dysfunction. In mouse models of HF, ...

Federal science agencies have renewed and increased funding for a world-renowned digital archive of protein structures housed ...

By focusing on AMPK activation, CarboFire addresses the enzyme deficiency that silently sabotages weight loss. Rather than ...