“The solution we are exploring is to transplant liver progenitor cells.” So far, Ochiya and his team have shown that mouse and rat hepatocytes extracted from livers, even damaged ...

The reason is that extensive post-transplant expansion is needed to establish and sustain a therapeutically effective liver cell mass in patients, a lesson learned from clinical trials of aHep ...

The activation of p-Smad2/3, signaling intermediates of transforming growth factor-beta (TGF-β), increased in hepatocytes after exposure of 0.25, 1, and 2 Gy of fast neutrons, but it was not detected ...

the proportion of liver-sinusoidal endothelial cells (LEC) with normal EC signatures was reduced. Moreover, RNA velocity analysis showed a strong directional flow from LEC to MaVEC in non-responders.

TUNEL Assay Kits were used to measure apoptotic cells in livers ... For histopathology, frozen sections of liver tissues were stained by Oil Red O working solution to determine the steatosis in liver ...