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Nature
4 年
Application Note: Scalable, more sensitive CRISPR screens
A targeted scRNA-seq approach on the BD Rhapsody Single Cell Analysis System reduces experimental cost while enhancing dynamic range and scalability Conventional single-cell RNA sequencing ...
生物谷
13 天
Nature:免疫系统的提前布局,T细胞如何为慢性感染“未雨绸缪”?
在对抗慢性感染和肿瘤的斗争中,T细胞衰竭(T cell exhaustion)是一个备受关注的领域。T细胞的衰竭状态使它们在面对长期的抗原暴露时功能减退,表现为效应功能削弱和细胞毒性因子的减少。这种现象不仅阻碍了 免疫 系统清除慢性病毒感染和 肿瘤细胞 的能力,还为新型免疫疗法的开发带来了重大挑战。然而,衰竭T细胞的前体是否只能在慢性感染中形成?或者,它们是否也能在急性感染的早期阶段被预先“部署” ...
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