Aminoacyl-tRNA synthetase aminoacylates the cognate transfer RNA (tRNA) with the cognate amino acid, which will be incorporated into the nascent polypeptide chain on the ribosome. In addition to ...
McC analogs with an altered terminal amino acid retain the Trojan-horse mechanism of action but target aminoacyl-tRNA synthetases specified by an amino acid coupled to AMP. Clustered homologs of E.
Defects in tRNA biology, such as mutations in tRNA genes or aminoacyl-tRNA synthetases, can lead to various diseases, including: Understanding the mechanisms of tRNA-related diseases and the potential ...
McC analogs with an altered terminal amino acid retain the Trojan-horse mechanism of action but target aminoacyl-tRNA synthetases specified by an amino acid coupled to AMP. Clustered homologs of E.