McC analogs with an altered terminal amino acid retain the Trojan-horse mechanism of action but target aminoacyl-tRNA synthetases specified by an amino acid coupled to AMP. Clustered homologs of E.
Aminoacyl-tRNA synthetase aminoacylates the cognate transfer RNA (tRNA) with the cognate amino acid, which will be incorporated into the nascent polypeptide chain on the ribosome. In addition to ...
Defects in tRNA biology, such as mutations in tRNA genes or aminoacyl-tRNA synthetases, can lead to various diseases, including: Understanding the mechanisms of tRNA-related diseases and the potential ...
Within the ribosome, the mRNA and aminoacyl-tRNA complexes are held together closely, which facilitates base-pairing. The rRNA catalyzes the attachment of each new amino acid to the growing chain.
McC analogs with an altered terminal amino acid retain the Trojan-horse mechanism of action but target aminoacyl-tRNA synthetases specified by an amino acid coupled to AMP. Clustered homologs of E.
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