Figure 6: The N-end rule pathway. Subunit selectivity of protein degradation was yet another fundamental feature of the ubiquitin system that was first discovered in the N-end rule pathway.

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), ...

In eukaryotic cells, a ubiquitin conjugation cascade pathway exists to enzymatically activate ubiquitin, which then becomes covalently attached to substrate proteins that are destined for proteolysis.

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), shedding light on potential therapeutic targets for combating tumor progression, ...

(Cited in nearly 120 publications as of February 1997) IN ON THE GROUND FLOOR: This review summarized the state of the field when many people were just starting to get interested in the ubiquitin ...

During ubiquitination, a group of enzymes called E3 ubiquitin ligases attach a small ... which investigates ubiquitination pathways in various physiological contexts, developed a simple, cost ...

A new review published in Genes & Diseases explores the pivotal role of the ubiquitin-proteasome system (UPS) in regulating the tumor microenvironment (TME) and driving cancer progression. The study ...

Amerigo Scientific releases transglutaminase inhibitors designed to advance research into their therapeutic applications across a range of diseases. These transglutaminase inhibitors seek to enable ...