Figure 6: The N-end rule pathway. Subunit selectivity of protein degradation was yet another fundamental feature of the ubiquitin system that was first discovered in the N-end rule pathway.

In eukaryotic cells, a ubiquitin conjugation cascade pathway exists to enzymatically activate ubiquitin, which then becomes covalently attached to substrate proteins that are destined for proteolysis.

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), ...

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), shedding light on potential therapeutic targets for combating tumor progression, ...

A new review published in Genes & Diseases explores the pivotal role of the ubiquitin-proteasome system (UPS) in regulating the tumor microenvironment (TME) and driving cancer progression. The study ...