Figure 1: a, Sequence alignment of SAM domains from the Eph family of receptor tyrosine kinases and selected proteins. In the Eph SAM dimer structure, the N– and C–termini of each domain are ...

The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling pathways is a current focus of the lab. The conformational activation of Src kinase ...