Trabectedin-DNA adducts are recognized by TC-NER and lead to an abortive reaction as these adducts block the incision of the XPG endonuclease, causing persistent XPF-mediated breaks. TRABI-Seq ...
Analysis of the DNA break patterns induced by trabectedin revealed that breaks are formed throughout the genome, but only at sites where active transcription and with it, TC-NER occurs. Using this ...