During development, stem and progenitor cells gradually commit to differentiation pathways. Cell fate decisions are regulated by differentiation factors, which activate transcription programmes ...
These are found in a mature organism. Their function is to replenish all of the types of (differentiated) cells found in that specific tissue. Tissue stem cells are multipotent. This means that ...
We investigate how stem cells perceive environmental changes and determine their cell fate, and how niches form and remodel the local environment during lung development, regeneration and disease ...
In the context of lung adenocarcinoma, which is a major form of cancer originating from AT2 cells, understanding how aging affects stem cell behavior is essential for advancing cancer prevention ...
The key to the UTMB team's success in getting the lung's blood vessel development started in the bioreactor was supplying stem ... stimulates cell growth, proliferation or the differentiation ...
Importantly, ontogeny of epidermal SCC parallels cancers associated with high mortality, including the SCC of the head and neck and the lung SCC. Tools for analysis of gene function ... the ...