Together, these studies uncover novel compensatory pathways that may be involved ... Key among these is the activation of signaling by RHO (another member of the RAS superfamily) and the up ...

Newly discovered estrogen receptor-dependent signaling pathways demonstrate that estrogen functions in the cytosol as well as in the nucleus. The classic estrogen receptor signaling pathway occurs ...

Human cell transformation systems revealed that RAL-GEF signaling is particularly required for oncogenic RAS function in human ... Co-opted pathways required by oncogenic KRAS in order to sustain ...

in tumors expressing different RAS, RAF, or NF1 mutants. We have shown that tumors with HER2 amplification or PI3K mutation are selectively dependent for growth on the PI3K pathway and are sensitive ...

By the late 1990s, scientists had managed to identify drugs that worked against mutant proteins that function in specific signaling pathways that cancer cells rely on—a step that ushered in a ...

In NF1, many of these medications work by blocking a specific cell signaling pathway called Ras/MAPK that is hyperactive in cells that have lost NF1 function due to gene mutation. When this signaling ...

About 20% of patients with RASopathies have HCM; RASopathy-associated HCM is often caused by genetic mutations in the RAS/MAPK signaling pathway, which regulates cell growth and development.

About 20% of patients with RASopathies have HCM; RASopathy-associated HCM is often caused by genetic mutations in the RAS/MAPK signaling pathway, which regulates cell growth and development.