The collection of proteins within a cell determines its health and function. Proteins are responsible for nearly every task of cellular life, including cell shape and inner organization ...

Small synthetic molecules (Capture Compounds ™) are used to interrogate native proteins. Using staurosporine as a selectivity function for a kinase-specific Capture Compound ™ enables ...

Kinases are enzymes which modify their targets to regulate many cell functions ... "Aurora-A is an incomplete kinase, which means it relies on protein-protein interactions to regulate where ...

G protein-coupled receptor kinase 2 (GRK2) is involved in heart failure (HF) progression and its upregulation contributes to adverse cardiac remodeling and dysfunction. In mouse models of HF, ...

For children with severe hypertrophic cardiomyopathy caused by gain-of-function RAS/mitogen-activated protein kinase (MAPK) mutations (RASopathy), trametinib reduces mortality and morbidity.

This modification regulates the activity, localization, and function of proteins, ultimately influencing various cellular ...