The modified tRNA base 2-thiouridine is required for many steps in translation. Surprisingly, the biosynthesis of this simple derivative requires a minimum of four sulfur transfer reactions ...

Wobble base pairing enables a single tRNA molecule to recognize multiple codons for the same amino acid, reducing the number of tRNA molecules required for translation. To ensure accurate translation, ...

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...