In brief, autophagy is a ubiquitous process in eukaryotic cells that results in the breakdown of cytoplasm within the lysosome in response ... as wide-ranging as cancer, neurodegeneration and ...
We have also recently discovered that depriving cells of essential amino acids and delivering specialized nanomaterials to the lysosome induces an iron-dependent form of cell death called ferroptosis ...
The lab also studies mechanisms that regulate autophagy protein and lysosome function in endocytic trafficking and nutrient homeostasis. Cell biologist Michael Overholtzer explores genes that make ...
I am a cell physiologist and my research lab uses genetics, biochemistry, advanced microscopy and synthetic biology to study: (1) fundamental lysosome biology in health and disease, and (2) ...