We used flow cytometry and microscopy to show that fluorescently-labeled pleural macrophages (PMs) migrate from the pleural cavity into the lung after infection with pH1N1 A/California/04/2009 ...

we employed tissue deconvolution and linear regression to model the lung immune cell changes that occurred during mild or severe influenza virus infections. Modeling accurately predicted known ...

In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.

They found that macrophages expressing Gpnmb genes, which have historically been described as "pro-fibrotic" macrophages, were found in both types of lung injury, indicating that they may not be ...

More information: Emily M. King et al, Gpnmb and Spp1 mark a conserved macrophage injury response masking fibrosis-specific programming in the lung, JCI Insight (2024). DOI: 10.1172/jci.insight.182700 ...