The AlkB reaction proceeds via methyl hydroxylation followed by fragmentation with concomitant release of formaldehyde, which is similar to the proposed histone demethylase mechanism. 1 ...

Among important epigenetic players are >60 human protein methyltransferases (PMTs), > 30 protein lysine demethylases (KDMs), and various methyl ... we focus on epigenetic writers (PMTs), readers ...