After preclinical studies suggested synergy between the two mechanisms of action, Byondis is now conducting ... for example, HER2-low breast cancer and ovarian cancer. “We hope that the ...

A significant breakthrough in breast cancer research has uncovered a key mechanism driving cancer invasion and drug resistance. A University of Liverpool study reveals how two critical molecules ...

On January 17, 2025, the Food and Drug Administration (FDA) approved datopotamab deruxtecan-dlnk a Trop-2-directed antibody ...

owing to the dramatic response observed in a subset of HER2-positive patients. The mechanisms of action are complex and not fully understood, and much effort has been spent in order to identify ...

Another possible mechanism of action is the preferential exertion of antibody- dependent cellular cytotoxicity on HER2-overexpressing cancer cells. [62] Trastuzumab contains an immunoglobulin G1 ...

However, in trastuzumab-resistant breast cancer cells, this intricate network breaks down. A key regulator in the network, GDI2, is lost, leading to disruption of the α V β 6-HER2 connection.As ...