preventing detoxification of lipid hydroperoxides and promoting LPO. This cascade leads to cellular dysfunction and death. The unique features of ferroptosis—iron dependency, ROS generation ...

Liposomes embedded with PEGylated ultrasmall iron oxide nanoparticles integrate ferroptosis activation, MRI tracing, and pH/ROS-sensitive drug delivery for combination cancer therapies.

Columbia researchers have found that a rare type of lipid is a key driver of ferroptosis, a form of cell death discovered by ...

These novel compounds induce a non-apoptotic, iron-dependent oxidative form of cell death that we refer to as ferroptosis. We have found that this form of cell death is distinct from apoptosis and ...

That could be transformative." More information: Kelly H. Sokol et al, Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking ...