Nature3mon
Unravelling the extracellular matrix
The extracellular matrix protein fibronectin forms fibrils when ... The FN III repeat (Fig. 1) is found in many proteins besides fibronectin, including the giant muscle protein titin, receptor ...
Hosted on MSN1mon
Liver fibrosis mechanism discovery presents a possible target for new therapies
Their findings have been published in the journal Gut. The study highlights the extracellular matrix protein 1 (ECM1) as a central component of potential new therapies aimed at preventing liver ...
BMJ3mon
Follistatin-like protein 1 regulates chondrocyte proliferation and chondrogenic differentiation of mesenchymal stem cells
uiowa.edu Objectives Chondrocytes, the only cells in the articular cartilage, play a pivotal role in osteoarthritis (OA) because they are responsible for maintenance of the extracellular matrix (ECM).
bjo.bmj2d
Prominent corneal nerves: a novel sign of lipoid proteinosis
Methods Ophthalmological examinations, chart review, ultrasound biomicroscopy, corneal confocal microscopic examinations with Nidek confoScan 4 and direct sequencing of the extracellular matrix ...
ahajournals.org10d
ECM Modifications Driven by Age and Metabolic Stress Directly Promote the Vascular Smooth Muscle Cell Osteogenic Processes
and ECM1 [ECM protein 1]) and cell-matrix adhesion (Figure 2C). Similar pathway changes were observed when comparing the late calcified ECM with the control, with the addition of extracellular exosome ...
Vitamin D and keloid scars: Researchers find inhibiting enzyme could lead to treatment
Keloids are fibrotic scars that extend beyond the boundaries of the original wound, often causing physical disfigurement and ...
Nature3y
Cell Signaling
In multicellular organisms, growth factors, hormones, neurotransmitters, and extracellular matrix components are ... fall into three major classes: G-protein-coupled receptors, ion channel ...
Extracellular vesicles contain ion channels that make cell-to-cell cargo transport possible
Scientists have revealed the secret to the structural integrity of tiny particles that transport cargo from cell to cell ...
BMJ1mon
A4.05 SMOC2, a secreted calcium-binding protein from cartilage extracellular matrix is an inhibitor of cartilage and bone formation
ΔCaBD cells however exhibited less of the inhibiting effects of Smoc2+ cells. Moreover we could observe partial restoration after addition of extracellular calcium to the culture medium of ...
BioWorld1mon
ADAMDEC1 as new therapeutic target for cholangiocarcinoma
A disintegrin and metalloprotease domain-like protein decysin-1 (ADAMDEC1) is a multifunctional transmembrane glycoprotein that has been shown to promote metastasis and development of various tumor ...
Helsinki2y
Cell surface and extracellular matrix molecules in neuronal development plasticity and disorders
In addition to heparin/heparan sulfates, HMGB1 binds to the immunoglobulin superfamily protein RAGE (receptor for advanced ... regulators of plasticity and regeneration in the CNS extracellular matrix ...