The common gamma-chain cytokines signal through cytokine receptors that consist of the common cytokine receptor γ chain (γc/CD132/IL2RG). This family includes at least six short-chain cytokines: IL2, ...

Binding of cytokines to their receptors results in the dimerization of receptor complexes and activation of the Janus family of protein tyrosine kinases (JAKs), followed by phosphorylation of the ...

Signaling by type I cytokines involves the formation of receptor homodimers, heterodimers or higher order receptor oligomers. Here we report the cloning of a type I cytokine receptor subunit that ...

Toll-like receptor 4 activation consequently produces an innate immune response in the brain that initiates the release of glial-derived neuroexcitatory and neurotoxic substances such as ...